TABLETLERDE GLİKLAZİT MİKTAR TAYİNİ İÇİN SPEKTROFOTOMETRİK YÖNTEM GELİŞTİRME VE DOĞRULAMA

Objective: A new spectrophotometric method for the gliclazide quantitation in dosage forms has been developedMaterial and Method: The subjects of study were modified-release tablets ("Diaglizide" 80 mg, "Diaglizide MR" 60 30 "Diabeton" MR "Gliklada" mg). As a reagent, bromocresol green acetone was used. Analytical equipment: spectrophotometer Specord 200, electronic scales АВТ-120-5DM.Result Discussion: It experimentally determined that reacts with medium at room temperature to form yellow product maximum absorption 411 nm. validated linearity, accuracy, precision, robustness. agent’s optimal concentration established stability investigated solutions checked by measuring their optical density minutes. Subordination Beer's law is observed range 62.00 - 94.00 mg/100 ml. limit detection 4.02∙10-6 g/ml, which indicates high sensitivity reaction. proposed according requirements State Pharmacopoeia Ukraine. results show developed simple affordable implement can be used determine drugs laboratories quality control forms.